Simparica Trio for XLarge Dogs 40.1 - 60kg Red
Simparica Trio Flea, Tick & Worm Treatment
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Simparica TRIO Flea, Tick and Worm Chewable Tablets for Extra Large Dogs 40.1-60kg
Extra large dogs explore the world on a grand scale - and they deserve protection that matches. Simparica TRIO Red pack is the all-in-one monthly chew delivering the highest dose in the TRIO range, formulated specifically for extra large dogs weighing 40.1 to 60kg. Each liver-flavoured chew contains sarolaner (72mg), moxidectin (1.44mg) and pyrantel (300mg) - a precision combination that provides vet-grade protection against fleas, paralysis ticks, deadly heartworm, roundworm, hookworm, mites, mange and the mosquitoes that spread heartworm. Whether your Rottweiler is patrolling acres of property, your Great Dane is bounding through the bush or your Saint Bernard is trekking mountain trails, TRIO keeps them covered for up to 35 days per dose. APVMA-approved, developed by Zoetis and trusted by veterinarians across Australia.
What Does Simparica TRIO Protect Against?
| Parasite | Coverage |
|---|---|
| Fleas (Ctenocephalides spp.) | Starts killing within 4 hours - kills before they lay eggs, preventing infestations and flea tapeworm |
| Paralysis Tick (Ixodes holocyclus) | Starts killing within 8 hours - treatment and control |
| Brown Dog Tick (Rhipicephalus sanguineus) | Treatment and control |
| Bush Tick (Haemaphysalis longicornis) | Treatment and control |
| Heartworm (Dirofilaria immitis) | 100% effective prevention - prevents new infection, kills juvenile heartworm and eliminates transmitting mosquitoes |
| Roundworm (Toxocara canis, Toxascaris leonina) | Treatment and control |
| Hookworm (Ancylostoma and Uncinaria spp.) | Treatment and control |
| Ear Mites (Otodectes cynotis) | Treatment and control |
| Demodex Mites (Demodex canis) | Treatment and control |
| Sarcoptic Mange (Sarcoptes scabiei) | Treatment and control |
| Mosquitoes (Aedes aegypti) | Eliminates mosquitoes that transmit heartworm |
Key Features and Benefits
- The only triple attack on heartworm - prevents new infection, kills juvenile heartworm already in the bloodstream and eliminates the mosquitoes that spread it
- Fast-acting - starts killing fleas within 4 hours and ticks within 8 hours
- Up to 35 days of protection per dose with no gaps in coverage
- All three key Australian ticks covered - paralysis tick, brown dog tick and bush tick
- Complete worm cover - heartworm, roundworm and hookworm treated and controlled in one chew
- Also treats ear mites, demodex mites, sarcoptic mange and flea allergy dermatitis
- Tasty liver-flavoured chew - given with or without food
- Safe for heartworm-positive dogs and well tolerated in avermectin-sensitive breeds including Collies
- Highest dose in the Simparica TRIO range - formulated for extra large dogs 40.1 to 60kg
- APVMA-approved and developed by Zoetis - trusted in animal health for 70+ years
Active Ingredients per Chew
| Ingredient | Amount per Chew | Role |
|---|---|---|
| Sarolaner | 72mg | Kills fleas, ticks and mites |
| Moxidectin | 1.44mg | Prevents heartworm and kills juvenile heartworm |
| Pyrantel | 300mg | Treats and controls roundworm and hookworm |
Product Details
| Feature | Detail |
|---|---|
| Brand | Simparica TRIO by Zoetis |
| Pack Colour | Red |
| Dog Weight Range | 40.1 - 60kg |
| Active Ingredients | Sarolaner 72mg, Moxidectin 1.44mg, Pyrantel 300mg per chew |
| Flavour | Liver |
| Dosage Frequency | Monthly - lasts up to 35 days |
| Minimum Age | 8 weeks |
| Pack Size | 3, 6 & 12 packs |
| Regulatory Approval | APVMA-approved |
| Made In | USA |
| Storage | Store below 30°C away from direct sunlight |
How to Give Simparica TRIO
- Weigh your dog and confirm they fall within the 40.1 to 60kg range before administering the Red pack. For dogs over 60kg, use the appropriate combination of tablets and consult your veterinarian.
- Give one chew monthly with or without food - most extra large dogs take it straight from the hand like a treat.
- For fussier dogs, pop the chew inside a small amount of food or place it directly into their mouth.
- Repeat every month year-round for continuous protection - there is no need to wait for tick or worm season.
- Missed a dose? Give it as soon as you remember and continue the regular monthly schedule from that point.
Simparica TRIO Size Guide
| Pack | Colour | Weight Range | Sarolaner | Moxidectin | Pyrantel |
|---|---|---|---|---|---|
| Puppy | Yellow | 1.25 - 2.5kg | 3mg | 0.06mg | 12.5mg |
| Extra Small | Purple | 2.6 - 5.0kg | 6mg | 0.12mg | 25mg |
| Small | Orange | 5.1 - 10kg | 12mg | 0.24mg | 50mg |
| Medium | Blue | 10.1 - 20kg | 24mg | 0.48mg | 100mg |
| Large | Green | 20.1 - 40kg | 48mg | 0.96mg | 200mg |
| Extra Large | Red | 40.1 - 60kg | 72mg | 1.44mg | 300mg |
Frequently Asked Questions
What is the difference between Simparica TRIO and regular Simparica? +
Regular Simparica protects against fleas, ticks and mites. Simparica TRIO does all of that and adds heartworm prevention, roundworm control and hookworm control in the same single monthly chew. TRIO contains three active ingredients - sarolaner, moxidectin and pyrantel - making it the most complete all-in-one parasite protection available in a single chew. For extra large dogs that cover significant ground outdoors, TRIO eliminates the need for separate heartworm and worming treatments.
Is the Red pack right for my extra large dog? +
The Red pack is designed for extra large dogs weighing between 40.1 and 60kg - covering some of Australia's biggest and most beloved breeds including Great Danes, Rottweilers, Bernese Mountain Dogs, Saint Bernards, Mastiffs, Irish Wolfhounds and larger Labradors and German Shepherds. Always weigh your dog before purchasing. For dogs weighing over 60kg, the appropriate combination of TRIO tablets should be used - consult your veterinarian for guidance on the correct dosing approach for your individual dog.
How does Simparica TRIO prevent heartworm in extra large dogs? +
Simparica TRIO takes a unique triple approach to heartworm protection. The moxidectin component prevents new heartworm infections from establishing, kills juvenile heartworm larvae already circulating in the bloodstream and the sarolaner component eliminates the Aedes aegypti mosquitoes that transmit heartworm. Together this delivers 100% effective heartworm prevention when given monthly year-round. Heartworm is transmitted by mosquitoes and is present across most of Australia year-round - making consistent monthly prevention critical for all extra large breed dogs regardless of lifestyle.
Can Simparica TRIO be given to heartworm-positive extra large dogs? +
Yes, Simparica TRIO is safe for use in heartworm-positive dogs. For extra large dogs switching from another heartworm prevention product, TRIO can be started within one month of the last dose. If you know or suspect your dog already has an existing heartworm infection - particularly relevant for dogs that may have had gaps in their prevention history - it is recommended to consult your veterinarian before starting TRIO so they can advise on the most appropriate approach.
Is Simparica TRIO safe for sensitive breeds? +
Yes. Simparica TRIO has a well-established safety profile and is well tolerated in avermectin-sensitive breeds including Collies. While most extra large breeds do not carry the avermectin sensitivity gene mutation, it is always worth mentioning to your veterinarian if your dog has known sensitivities or underlying health conditions before starting any new medication.
Does Simparica TRIO protect against paralysis ticks? +
Yes. Simparica TRIO provides treatment and control of all three key Australian ticks - paralysis tick (Ixodes holocyclus), brown dog tick (Rhipicephalus sanguineus) and bush tick (Haemaphysalis longicornis). Extra large dogs that spend time on rural properties, in bushland or near coastal areas are regularly exposed to tick habitat. TRIO starts killing ticks within 8 hours of dosing and consistent monthly administration provides continuous year-round protection.
My extra large dog is on joint or other medications - can I still use TRIO? +
Simparica TRIO is generally well tolerated alongside other medications. Extra large and giant breeds are often prescribed joint supplements, anti-inflammatory medications, thyroid treatments or other ongoing therapies given the health conditions more common in larger dogs. If your dog is currently receiving any other treatments or supplements, it is worth checking with your veterinarian before starting TRIO to make sure there are no concerns specific to your dog's health profile.
What if I miss a dose? +
Give Simparica TRIO as soon as you remember and then resume the regular monthly schedule from that point. Each dose provides up to 35 days of protection. For heartworm prevention specifically, consistent year-round monthly dosing without gaps is strongly recommended - gaps in heartworm prevention can leave your dog vulnerable to infection and may require veterinary assessment before restarting. A free monthly reminder service is available at zoetis.com.au/pet-reminders.
Are there any side effects? +
Simparica TRIO has a strong safety record and is recommended by veterinarians across Australia. Side effects are uncommon but the most frequently reported include vomiting, diarrhoea and lethargy. Less commonly, reduced appetite, increased thirst and restlessness have been observed. In very rare cases, seizures have been reported. Extra large breeds with a known history of neurological conditions are worth flagging with your veterinarian before starting. If you notice anything unusual after giving your dog Simparica TRIO, contact your veterinarian promptly or call the Zoetis support line on 1800 814 883.
How do I check my extra large dog for ticks? +
Extra large dogs with thick or double coats require a particularly thorough tick check after time spent in bushland, long grass or coastal scrub. Run your fingers slowly through the entire coat against the direction of hair growth, paying close attention to the head, neck, around the ears, between toes, armpits, groin and around the tail base - common tick attachment sites. Despite thorough checking, ticks can be missed on large dogs with dense coats which is why consistent monthly TRIO protection is so important. TRIO kills paralysis ticks within 8 hours of attachment, providing a critical safety net even when a tick goes undetected.
Please note: Always read the label and follow directions for use. Suitable for dogs and puppies from 8 weeks of age weighing at least 1.25kg. Not suitable for cats or other animals. Safe for heartworm-positive dogs and well tolerated in avermectin-sensitive breeds including Collies. Not evaluated for use in pregnant, lactating or breeding dogs - consult your veterinarian if applicable. For dogs over 60kg use the appropriate combination of whole tablets and consult your veterinarian. Store below 30°C away from direct sunlight and out of reach of children and animals. Keep in original packaging until use. For further information contact the Zoetis Veterinary Medical Information and Product Support Team on 1800 814 883 or email productsupport.au@zoetis.com.
(ZSR)
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