Simparica TRIO Flea, Tick and Worm Chewable Tablets for Medium Dogs 10.1-20kg
Medium dogs are often the most adventurous of the lot - and Simparica TRIO Blue pack is formulated to keep pace with every muddy walk, beach run and backyard dig. Designed specifically for medium dogs weighing 10.1 to 20kg, each liver-flavoured chew delivers a precise combination of sarolaner (24mg), moxidectin (0.48mg) and pyrantel (100mg) for complete all-in-one monthly parasite protection. Whether it is paralysis ticks in the long grass, heartworm-carrying mosquitoes on a warm evening or intestinal worms picked up at the dog park - TRIO tackles all of it in one easy monthly chew. APVMA-approved, developed by Zoetis and trusted by veterinarians across Australia - complete protection for your medium dog, every month, year-round.
What Does Simparica TRIO Protect Against?
| Parasite |
Coverage |
| Fleas (Ctenocephalides spp.) |
Starts killing within 4 hours - kills before they lay eggs, preventing infestations and flea tapeworm |
| Paralysis Tick (Ixodes holocyclus) |
Starts killing within 8 hours - treatment and control |
| Brown Dog Tick (Rhipicephalus sanguineus) |
Treatment and control |
| Bush Tick (Haemaphysalis longicornis) |
Treatment and control |
| Heartworm (Dirofilaria immitis) |
100% effective prevention - prevents new infection, kills juvenile heartworm and eliminates transmitting mosquitoes |
| Roundworm (Toxocara canis, Toxascaris leonina) |
Treatment and control |
| Hookworm (Ancylostoma and Uncinaria spp.) |
Treatment and control |
| Ear Mites (Otodectes cynotis) |
Treatment and control |
| Demodex Mites (Demodex canis) |
Treatment and control |
| Sarcoptic Mange (Sarcoptes scabiei) |
Treatment and control |
| Mosquitoes (Aedes aegypti) |
Eliminates mosquitoes that transmit heartworm |
Key Features and Benefits
- The only triple attack on heartworm - prevents new infection, kills juvenile heartworm already in the bloodstream and eliminates the mosquitoes that spread it
- Fast-acting - starts killing fleas within 4 hours and ticks within 8 hours
- Up to 35 days of protection per dose with no gaps in coverage
- All three key Australian ticks covered - paralysis tick, brown dog tick and bush tick
- Complete worm cover - heartworm, roundworm and hookworm treated and controlled in one chew
- Also treats ear mites, demodex mites, sarcoptic mange and flea allergy dermatitis
- Tasty liver-flavoured chew - easy to give with or without food
- Safe from 8 weeks of age and well tolerated in avermectin-sensitive breeds including Collies
- APVMA-approved and developed by Zoetis - trusted in animal health for 70+ years
- Formulated for medium dogs 10.1 to 20kg - Blue pack
- Available in multiple pack sizes
Active Ingredients per Chew
| Ingredient |
Amount per Chew |
Role |
| Sarolaner |
24mg |
Kills fleas, ticks and mites |
| Moxidectin |
0.48mg |
Prevents heartworm and kills juvenile heartworm |
| Pyrantel |
100mg |
Treats and controls roundworm and hookworm |
Product Details
| Feature |
Detail |
| Brand |
Simparica TRIO by Zoetis |
| Pack Colour |
Blue |
| Dog Weight Range |
10.1 - 20kg |
| Active Ingredients |
Sarolaner 24mg, Moxidectin 0.48mg, Pyrantel 100mg per chew |
| Flavour |
Liver |
| Dosage Frequency |
Monthly - lasts up to 35 days |
| Minimum Age |
8 weeks |
| Pack Sizes Available |
3, 6 and 12 chewable tablets |
| Regulatory Approval |
APVMA-approved |
| Made In |
USA |
| Storage |
Store below 30°C away from direct sunlight |
How to Give Simparica TRIO
- Weigh your dog and confirm they fall within the 10.1 to 20kg range before administering the Blue pack.
- Give one chew monthly with or without food - most medium dogs take it straight from the hand like a treat.
- For fussier dogs, pop the chew inside a small amount of food or place it directly into their mouth.
- Repeat every month year-round for continuous protection - no need to wait for tick or worm season.
- Missed a dose? Give it as soon as you remember and continue the regular monthly schedule from that point.
Simparica TRIO Size Guide
| Pack |
Colour |
Weight Range |
Sarolaner |
Moxidectin |
Pyrantel |
| Puppy |
Yellow |
1.25 - 2.5kg |
3mg |
0.06mg |
12.5mg |
| Extra Small |
Purple |
2.6 - 5.0kg |
6mg |
0.12mg |
25mg |
| Small |
Orange |
5.1 - 10kg |
12mg |
0.24mg |
50mg |
| Medium |
Blue |
10.1 - 20kg |
24mg |
0.48mg |
100mg |
| Large |
Green |
20.1 - 40kg |
48mg |
0.96mg |
200mg |
| Extra Large |
Red |
40.1 - 60kg |
72mg |
1.44mg |
300mg |
Frequently Asked Questions
What is the difference between Simparica TRIO and regular Simparica? +
Regular Simparica protects against fleas, ticks and mites. Simparica TRIO adds heartworm prevention, roundworm control and hookworm control in the same single monthly chew - three active ingredients working together for complete all-in-one parasite protection. For medium dogs that are active outdoors, attend dog parks, socialise with other dogs or live in areas where mosquitoes are present - which is most of Australia - TRIO eliminates the need for separate heartworm and intestinal worm treatments alongside your flea and tick prevention.
Is the Blue pack right for my medium dog? +
The Blue pack is designed for medium dogs weighing between 10.1 and 20kg. This covers many of Australia's most popular medium breeds including Beagles, Border Collies, Spaniels, Whippets, Staffordshire Bull Terriers, Bulldogs and Australian Terriers. Always weigh your dog before purchasing - particularly as growing dogs transition between pack sizes - to confirm the Blue pack is correct. If your dog sits on the boundary between 20 and 20.1kg speak with your veterinarian about which pack is most appropriate.
How does Simparica TRIO prevent heartworm? +
Simparica TRIO is the only product that takes a triple approach to heartworm. The moxidectin component prevents new heartworm infections from establishing and kills juvenile heartworm larvae already circulating in the bloodstream. At the same time, the sarolaner component eliminates the Aedes aegypti mosquitoes that transmit heartworm in the first place - closing the transmission cycle at both ends. Together this delivers 100% effective heartworm prevention when given every month year-round. Heartworm is present across most of Australia regardless of season and is transmitted by mosquitoes - making year-round prevention essential for medium breed dogs.
Does Simparica TRIO protect against paralysis ticks? +
Yes. Simparica TRIO provides treatment and control of all three key Australian ticks - paralysis tick (Ixodes holocyclus), brown dog tick (Rhipicephalus sanguineus) and bush tick (Haemaphysalis longicornis). Medium dogs are often the most active and outdoorsy of all size categories - regularly hiking, visiting coastal areas and exploring bushland where paralysis ticks are commonly found. TRIO starts killing paralysis ticks within 8 hours of dosing and consistent year-round monthly dosing provides uninterrupted protection throughout every season.
Is Simparica TRIO safe for Collies and avermectin-sensitive breeds? +
Yes. Simparica TRIO has a well-established safety profile and is well tolerated in avermectin-sensitive breeds including Collies, Shetland Sheepdogs, Australian Shepherds and other breeds that may carry the MDR1 gene mutation affecting drug sensitivity. Some of these breeds fall within the medium size range. If your dog has any known sensitivities or health conditions, it is always worth confirming with your veterinarian that TRIO is appropriate for your individual dog before starting.
My medium dog attends dog parks and doggy daycare - why is intestinal worm cover important? +
Shared environments like dog parks, daycare facilities and off-leash areas are among the most common sources of intestinal worm exposure for medium dogs. Roundworm and hookworm eggs persist in soil and on surfaces and are easily picked up through normal sniffing and licking behaviour. Roundworm in particular can also be transmitted to humans through contact with contaminated soil or dog faeces - an important consideration for families with children. TRIO treats and controls both roundworm and hookworm monthly alongside its complete parasite coverage, simplifying protection for socially active dogs.
Can Simparica TRIO be given to heartworm-positive dogs? +
Yes, Simparica TRIO is safe for use in heartworm-positive dogs. For medium dogs switching from another heartworm prevention product, TRIO can be started within one month of the last dose. If you know or suspect your dog already has an existing heartworm infection it is recommended to speak with your veterinarian before starting TRIO so they can advise on the most appropriate management approach for your dog's situation.
Can Simparica TRIO be given alongside other medications? +
Simparica TRIO is generally well tolerated alongside other medications. If your medium dog is currently receiving any other treatments, supplements or medications it is worth mentioning this to your veterinarian before starting TRIO to make sure there are no concerns specific to your dog's health profile or current medication regime.
What if I miss a dose? +
Give Simparica TRIO as soon as you remember and then continue the regular monthly schedule from that point. Each dose provides up to 35 days of protection so there is a small buffer built in. For heartworm prevention specifically, consistent year-round monthly dosing without gaps is strongly recommended. A free monthly reminder service is available at zoetis.com.au/pet-reminders to help you stay on track.
Are there any side effects? +
Simparica TRIO has a strong safety record and is recommended by veterinarians across Australia. Side effects are uncommon but the most frequently reported include vomiting, diarrhoea and lethargy. Less commonly, reduced appetite, increased thirst and restlessness have been observed. In very rare cases, seizures have been reported. If you notice anything unusual after giving your medium dog Simparica TRIO, contact your veterinarian promptly or call the Zoetis support line on 1800 814 883.
Please note: Always read the label and follow directions for use. Suitable for dogs and puppies from 8 weeks of age weighing at least 1.25kg. Not suitable for cats or other animals. Safe for heartworm-positive dogs and well tolerated in avermectin-sensitive breeds including Collies. Not evaluated for use in pregnant, lactating or breeding dogs - consult your veterinarian if applicable. Store below 30°C away from direct sunlight and out of reach of children and animals. Keep in original packaging until use. For further information contact the Zoetis Veterinary Medical Information and Product Support Team on 1800 814 883 or email productsupport.au@zoetis.com.