Simparica Trio for Large Dogs 20.1 - 40kg Green
Simparica Trio Flea, Tick & Worm Treatment
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Simparica TRIO Flea, Tick and Worm Chewable Tablets for Large Dogs 20.1-40kg
Large dogs live big lives - and the world they explore is full of uninvited passengers. Simparica TRIO is the all-in-one monthly chew that gives your large dog vet-grade protection against fleas, paralysis ticks, deadly heartworm, roundworm, hookworm, mites, mange and even the mosquitoes that spread heartworm - all in a single liver-flavoured chew. The Green pack is formulated specifically for large dogs weighing 20.1 to 40kg, delivering a precise combination of sarolaner (48mg), moxidectin (0.96mg) and pyrantel (200mg) per chew. APVMA-approved and developed by Zoetis - the world's leading animal health company with over 70 years of specialised scientific expertise - TRIO gives your big dog complete parasite protection, every month, year-round.
What Does Simparica TRIO Protect Against?
| Parasite | Coverage |
|---|---|
| Fleas (Ctenocephalides spp.) | Starts killing within 4 hours - kills before they lay eggs, preventing infestations and flea tapeworm |
| Paralysis Tick (Ixodes holocyclus) | Starts killing within 8 hours - treatment and control |
| Brown Dog Tick (Rhipicephalus sanguineus) | Treatment and control |
| Bush Tick (Haemaphysalis longicornis) | Treatment and control |
| Heartworm (Dirofilaria immitis) | 100% effective prevention - prevents new infection, kills juvenile heartworm and eliminates transmitting mosquitoes |
| Roundworm (Toxocara canis, Toxascaris leonina) | Treatment and control |
| Hookworm (Ancylostoma and Uncinaria spp.) | Treatment and control |
| Ear Mites (Otodectes cynotis) | Treatment and control |
| Demodex Mites (Demodex canis) | Treatment and control |
| Sarcoptic Mange (Sarcoptes scabiei) | Treatment and control |
| Mosquitoes (Aedes aegypti) | Eliminates mosquitoes that transmit heartworm |
Key Features and Benefits
- The only triple attack on heartworm - prevents new infection, kills juvenile heartworm already in the bloodstream and eliminates the mosquitoes that spread it
- Fast-acting - starts killing fleas within 4 hours and ticks within 8 hours
- Up to 35 days of protection per dose with no gaps in coverage
- All three key Australian ticks covered - paralysis tick, brown dog tick and bush tick
- Complete worm cover - heartworm, roundworm and hookworm treated and controlled in one chew
- Also treats ear mites, demodex mites, sarcoptic mange and flea allergy dermatitis
- Tasty liver-flavoured chew - given with or without food
- Safe for heartworm-positive dogs and well tolerated in avermectin-sensitive breeds including Collies
- APVMA-approved and developed by Zoetis - trusted in animal health for 70+ years
- Formulated for large dogs 20.1 to 40kg - Green pack
- 3 chews per pack - 3 months supply
Active Ingredients per Chew
| Ingredient | Amount per Chew | Role |
|---|---|---|
| Sarolaner | 48mg | Kills fleas, ticks and mites |
| Moxidectin | 0.96mg | Prevents heartworm and kills juvenile heartworm |
| Pyrantel | 200mg | Treats and controls roundworm and hookworm |
Product Details
| Feature | Detail |
|---|---|
| Brand | Simparica TRIO by Zoetis |
| Pack Colour | Green |
| Dog Weight Range | 20.1 - 40kg |
| Active Ingredients | Sarolaner 48mg, Moxidectin 0.96mg, Pyrantel 200mg per chew |
| Flavour | Liver |
| Dosage Frequency | Monthly - lasts up to 35 days |
| Minimum Age | 8 weeks |
| Pack Size | 3, 6 & 12 packs |
| Regulatory Approval | APVMA-approved |
| Made In | USA |
| Storage | Store below 30°C away from direct sunlight |
How to Give Simparica TRIO
- Weigh your dog and confirm they fall within the 20.1 to 40kg range before administering the Green pack.
- Give one chew monthly with or without food - most large dogs take it straight from the hand like a treat.
- For fussier dogs, pop the chew inside a small amount of food or place it directly into their mouth.
- Repeat every month year-round for continuous protection - there is no need to wait for tick or worm season.
- Missed a dose? Give it as soon as you remember and continue the regular monthly schedule from that point.
Simparica TRIO Size Guide
| Pack | Colour | Weight Range | Sarolaner | Moxidectin | Pyrantel |
|---|---|---|---|---|---|
| Puppy | Yellow | 1.25 - 2.5kg | 3mg | 0.06mg | 12.5mg |
| Extra Small | Purple | 2.6 - 5.0kg | 6mg | 0.12mg | 25mg |
| Small | Orange | 5.1 - 10kg | 12mg | 0.24mg | 50mg |
| Medium | Blue | 10.1 - 20kg | 24mg | 0.48mg | 100mg |
| Large | Green | 20.1 - 40kg | 48mg | 0.96mg | 200mg |
| Extra Large | Red | 40.1 - 60kg | 72mg | 1.44mg | 300mg |
Frequently Asked Questions
What is the difference between Simparica TRIO and regular Simparica? +
Regular Simparica protects against fleas, ticks and mites. Simparica TRIO does all of that and adds heartworm prevention, roundworm control and hookworm control in the same single monthly chew. TRIO contains three active ingredients - sarolaner, moxidectin and pyrantel - making it a complete all-in-one parasite protection solution. For large active dogs that are regularly exposed to the outdoors, TRIO provides the most comprehensive coverage available in a single chew.
Is the Green pack right for my large dog? +
The Green pack is designed for large dogs weighing between 20.1 and 40kg - a range that covers many of Australia's most popular large breeds including Labradors, Golden Retrievers, German Shepherds, Border Collies, Boxers, Weimaraners and Standard Poodles. Always weigh your dog before purchasing, particularly with growing dogs. If your dog sits right on the 40kg boundary, speak with your veterinarian about whether to continue with the Green pack or move to the Red (Extra Large) pack.
How does Simparica TRIO prevent heartworm? +
Simparica TRIO takes a unique triple approach to heartworm that no other product matches. The moxidectin component prevents new heartworm infections from taking hold, kills juvenile heartworm larvae already circulating in the bloodstream and the sarolaner component eliminates the Aedes aegypti mosquitoes that transmit heartworm in the first place. Together this triple action provides 100% effective heartworm prevention when given monthly year-round. Heartworm is transmitted by mosquitoes and is present year-round across most of Australia - making monthly prevention essential for all large breed dogs.
Can Simparica TRIO be given to heartworm-positive dogs? +
Yes, Simparica TRIO is safe for use in heartworm-positive dogs. For large dogs switching from another heartworm prevention product, TRIO can be started within one month of the last dose. If you know or suspect your dog has an existing heartworm infection, it is recommended to consult your veterinarian before starting TRIO so they can advise on the most appropriate approach for your dog's situation.
Is Simparica TRIO safe for Collies and sensitive breeds? +
Yes. Simparica TRIO has a well-established safety profile and is well tolerated in avermectin-sensitive breeds including Collies. This is an important distinction as some large breed parasite prevention products are not suitable for Collies and related breeds due to a genetic mutation affecting drug sensitivity. If your dog has known sensitivities or underlying health conditions, it is always worth confirming with your veterinarian before starting any new medication.
Does Simparica TRIO protect against paralysis ticks? +
Yes. Simparica TRIO provides treatment and control of all three key Australian ticks - paralysis tick (Ixodes holocyclus), brown dog tick (Rhipicephalus sanguineus) and bush tick (Haemaphysalis longicornis). Large dogs who regularly explore bushland, national parks or coastal areas are particularly exposed to paralysis tick risk. TRIO starts killing ticks within 8 hours of dosing and monthly administration provides continuous uninterrupted protection throughout the year.
Can Simparica TRIO be given with other medications? +
Simparica TRIO is generally well tolerated alongside other medications. Large breeds are often prescribed joint supplements, anti-inflammatory medications or other ongoing treatments. If your dog is currently receiving any other treatments or supplements, it is worth checking with your veterinarian before starting TRIO to make sure there are no concerns specific to your dog's health history or current medication regime.
What if I miss a dose? +
Give Simparica TRIO as soon as you remember and then continue the regular monthly schedule from that point. Each dose provides up to 35 days of protection so there is a small buffer built in, but for heartworm prevention in particular consistent year-round monthly dosing without gaps is strongly recommended. A free monthly reminder is available at zoetis.com.au/pet-reminders to help you stay on track.
Are there any side effects? +
Simparica TRIO has a strong safety record and is recommended by veterinarians across Australia. Side effects are uncommon but the most frequently reported include vomiting, diarrhoea and lethargy. Less commonly, reduced appetite, increased thirst and restlessness have been observed. In very rare cases, seizures have been reported. If you notice anything unusual after giving your large dog Simparica TRIO, contact your veterinarian promptly or call the Zoetis support line on 1800 814 883.
Please note: Always read the label and follow directions for use. Suitable for dogs and puppies from 8 weeks of age weighing at least 1.25kg. Not suitable for cats or other animals. Safe for heartworm-positive dogs and well tolerated in avermectin-sensitive breeds including Collies. Not evaluated for use in pregnant, lactating or breeding dogs - consult your veterinarian if applicable. Store below 30°C away from direct sunlight and out of reach of children and animals. Keep in original packaging until use. For further information contact the Zoetis Veterinary Medical Information and Product Support Team on 1800 814 883 or email productsupport.au@zoetis.com.
(ZSG)
| SKU | ZSG |
| Brand | Simparica Trio |
| Shipping Weight | 0.1000kg |
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