Zylkene Calming Supplement for Dogs & Cats

Australia's number 1 calming supplement for dogs and cats. Natural alpha-casozepine capsules for anxiety, fireworks, separation stress, travel and life changes.

3 Products Found

Zylkene 100 Pack Blister - 75mg Capsules (100 Capsules) **MAKE SURE THIS IS 100&

$87.65

Zylkene Plus

From$40.52

Zylkene

3 Reviews

From$38.08

Anxiety in dogs and cats is more common than most pet owners realise, and it shows up in ways that are not always immediately obvious. Hiding during fireworks, refusing to eat before a vet visit, excessive grooming in cats, destructive behaviour when left alone, toileting in unusual places, restlessness that seems to have no clear cause. These are all signs that a dog or cat is not coping with something in their environment, and they deserve to be taken seriously. Zylkene is Australia's number one calming supplement for both dogs and cats, a natural, non-sedating option backed by clinical data and recommended by vets across the country. At The Vet Shed we stock the full Zylkene range.

How Zylkene Works

Zylkene's active ingredient is alpha-casozepine, a bioactive peptide derived from a protein found in cow's milk called alpha-S1 casein. Alpha-casozepine has an affinity for GABA receptors in the brain, the same receptors involved in the calming effect produced by benzodiazepine medications, but without the sedation, dependency risk or prescription requirements associated with pharmaceutical anxiolytics. The calming effect is gentle and natural, helping pets feel less reactive to stressful situations without dulling their senses or making them drowsy.

The mechanism has an intuitive parallel in the calming effect that nursing has on newborn mammals. The same casein proteins that make warm milk calming for babies exert a similar calming influence through alpha-casozepine in adult dogs and cats when delivered as a concentrated supplement.

When to Use Zylkene

Zylkene is used both for anticipated stressful events and for ongoing management of generalised anxiety. Common situations where Zylkene is recommended include fireworks and thunderstorms, vet and grooming visits, travel and car journeys, kennelling and cattery stays, moving house, introducing a new pet or baby to the home, changes in routine or household composition, and separation anxiety when left alone. For predictable events, Zylkene can be started one to two days before the stressor and continued through the event. For ongoing anxiety, consistent daily use builds and maintains the calming effect over time.

Zylkene Products at The Vet Shed

Zylkene Capsules - The original Zylkene formula containing alpha-casozepine, available in 75mg for cats and small dogs, 225mg for medium dogs and 450mg for large dogs. The capsules can be given whole with food or opened and the contents sprinkled over a meal, making administration flexible for pets that resist tablet-taking. Available in multiple pack sizes.
Zylkene Plus - An enhanced formulation combining alpha-casozepine with additional ingredients to provide a more comprehensive calming effect. Suited to pets with more significant anxiety or those who have not responded fully to standard Zylkene alone.
Zylkene 75mg Capsules 100 Pack Blister - The 100-capsule blister pack of the 75mg dose, ideal for ongoing daily use in cats and small dogs where a larger supply reduces reordering frequency and cost per dose.

Signs Your Pet May Benefit from Zylkene

Dogs and cats express anxiety differently and not all signs are dramatic. In dogs, watch for excessive barking or whining, restlessness, yawning or drooling in stressful situations, hiding or cowering, changes in appetite and destructive behaviour. In cats, look for hiding, overgrooming, changes in litter box use, reduced appetite, reduced play and activity, or excessive vocalisation. Any of these behaviours appearing in a new or worsening pattern warrants a conversation with your vet to rule out underlying medical causes, after which Zylkene is a well-established first-line supplement option worth discussing.

Why Buy Zylkene at The Vet Shed

The Vet Shed stocks the full Zylkene range with competitive pricing and fast shipping across Australia. Zylkene is a genuine, clinically supported product that has earned its place as Australia's top-selling calming supplement through real-world results rather than marketing alone. For pets that struggle with anxiety, it is one of the most accessible and effective non-prescription options available.

FAQs About Zylkene

Is Zylkene safe for long-term daily use?

Yes. Zylkene is a natural supplement derived from milk protein and is safe for continuous long-term use in dogs and cats. It does not carry the dependency risk, tolerance development or side effect profile associated with pharmaceutical sedatives or anxiolytics. It is suitable for use in pets of all ages including puppies, kittens and elderly animals. If your pet has a dairy allergy or intolerance, consult your vet before using as the product is derived from milk protein.

How is Zylkene different from Zylkene Plus?

The original Zylkene contains alpha-casozepine as its sole active ingredient, which is appropriate for most pets with mild to moderate anxiety and for use around specific stressful events. Zylkene Plus combines alpha-casozepine with additional calming ingredients for a broader effect, suited to pets with more significant anxiety or those that have not achieved adequate response from standard Zylkene. Your vet can help guide which version is most appropriate for your individual pet.

How long before a stressful event should I start Zylkene?

For anticipated events like fireworks, travel or a vet visit, starting Zylkene one to two days before the stressor and continuing through the event gives the best results. For ongoing anxiety management, consistent daily supplementation is recommended to maintain a steady baseline of the calming effect. Unlike fast-acting sedatives, Zylkene works best as a proactive supplement rather than a last-minute intervention on the day of an event.

Does Zylkene sedate my pet?

No. Zylkene is non-sedating. It works by modulating the GABA receptor pathway in a gentle way that reduces anxiety reactivity without causing drowsiness, disorientation or the dulled responses associated with sedative medications. Pets on Zylkene remain alert and functional, simply less reactive to the situations that previously caused them distress. This makes it appropriate for use before events where you still need your pet to function normally, such as travel or social situations.

What dose of Zylkene does my pet need?

Zylkene is available in three strengths to match different body weights. The 75mg capsule is for cats and small dogs up to approximately 10kg. The 225mg capsule suits medium dogs from roughly 10 to 30kg. The 450mg capsule is for large dogs over 30kg. Always follow the dosing instructions on the packaging or your vet's specific guidance for your individual pet. The 100-pack blister of the 75mg capsule is the most economical option for ongoing daily use in cats and small dogs.

Can I use Zylkene alongside other anxiety treatments?

Yes. Zylkene can be used alongside other calming interventions including pheromone products like Adaptil and Feliway, behavioural modification programs and where relevant, veterinary prescribed medications. It is a natural supplement without known drug interactions, though it is always worth informing your vet of all supplements your pet is receiving if they are also on prescribed medications. For pets with severe anxiety, a multi-modal approach combining Zylkene with behavioural therapy and veterinary guidance typically produces the best outcomes.

Where can I buy Zylkene in Australia?

You can buy the full Zylkene range right here at The Vet Shed. We stock Zylkene capsules in all three strengths, Zylkene Plus and the 75mg 100-capsule blister pack, with fast shipping to addresses across Australia.